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Iichiro Shimomura Selected Research

Hypoadiponectinemia

1/2017Multiple Gouty Tophi with Bone Erosion and Destruction: A Report of an Early-onset Case in an Obese Patient.
1/2014Tracing the movement of adiponectin in a parabiosis model of wild-type and adiponectin-knockout mice.
1/2014Adiponectin as a routine clinical biomarker.
6/2012Molecular mechanisms of diabetes and atherosclerosis: role of adiponectin.
5/2012Visceral adiposity as a target for the management of the metabolic syndrome.
1/2011Relationships between circulating adiponectin levels and fat distribution in obese subjects.
1/2011Nocturnal falls of adiponectin levels in sleep apnea with abdominal obesity and impact of hypoxia-induced dysregulated adiponectin production in obese murine mesenteric adipose tissue.
8/2010Lack of adiponectin promotes formation of cholesterol gallstones in mice.
7/2010Adiponectin deficiency enhanced the severity of cerulein-induced chronic pancreatitis in mice.
4/2009Adiponectin ameliorates hypoxia-induced pulmonary arterial remodeling.
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Iichiro Shimomura Research Topics

Disease

103Type 2 Diabetes Mellitus (MODY)
06/2022 - 07/2002
65Obesity
01/2022 - 04/2002
64Insulin Resistance
06/2022 - 05/2002
42Atherosclerosis
09/2022 - 09/2002
34Cardiovascular Diseases (Cardiovascular Disease)
01/2022 - 03/2007
31Metabolic Syndrome (Dysmetabolic Syndrome X)
10/2019 - 07/2002
22Hypoadiponectinemia
01/2017 - 09/2002
21Neoplasms (Cancer)
01/2022 - 01/2004
21Hypertension (High Blood Pressure)
07/2021 - 01/2003
20Inflammation (Inflammations)
01/2022 - 09/2006
20Type 1 Diabetes Mellitus (Autoimmune Diabetes)
01/2022 - 01/2010
18Hyperglycemia
01/2022 - 03/2005
16Diabetes Mellitus
09/2022 - 01/2003
16Hypoglycemia (Reactive Hypoglycemia)
04/2022 - 01/2012
14Coronary Artery Disease (Coronary Atherosclerosis)
04/2022 - 04/2002
14Body Weight (Weight, Body)
04/2022 - 09/2003
12Abdominal Obesity
07/2021 - 01/2003
12Glucose Intolerance
01/2021 - 01/2009
10Hypertriglyceridemia
09/2022 - 06/2003
10Dyslipidemias (Dyslipidemia)
07/2021 - 01/2003
10Cushing Syndrome
03/2021 - 01/2013
10Carotid Artery Diseases
01/2020 - 11/2005
9Hypoxia (Hypoxemia)
01/2018 - 10/2006
8Diabetic Retinopathy (Retinopathy, Diabetic)
06/2021 - 07/2010
7Hyperinsulinism (Hyperinsulinemia)
03/2022 - 10/2002
7Heart Failure
03/2021 - 09/2005
6Diabetic Nephropathies (Diabetic Nephropathy)
09/2022 - 01/2013
5Peripheral Arterial Disease
04/2022 - 07/2012
5Fibrosis (Cirrhosis)
01/2022 - 09/2007
5Hyperaldosteronism (Conn Syndrome)
01/2022 - 01/2017
5Weight Loss (Weight Reduction)
01/2021 - 03/2012
5Pituitary Neoplasms (Pituitary Adenoma)
12/2019 - 01/2012
5Atherosclerotic Plaque (Atheroma)
07/2019 - 07/2007
5Acromegaly
01/2019 - 01/2012
5Chronic Limb-Threatening Ischemia
07/2014 - 12/2010
5Mason-Type Diabetes
12/2008 - 04/2005
5Vascular Diseases (Vascular Disease)
04/2008 - 04/2002
4Pancreatitis
09/2022 - 01/2010
4Hyperuricemia
04/2022 - 06/2011
4Metabolic Diseases (Metabolic Disease)
01/2022 - 01/2013
4Fatty Liver
06/2021 - 09/2003
4Diabetic Neuropathies (Diabetic Neuropathy)
12/2019 - 01/2011
4Non-alcoholic Fatty Liver Disease
01/2019 - 05/2005
4Hypertrophy
01/2019 - 09/2003

Drug/Important Bio-Agent (IBA)

105AdiponectinIBA
01/2022 - 05/2002
72Glucose (Dextrose)FDA LinkGeneric
06/2022 - 10/2002
61Insulin (Novolin)FDA Link
09/2022 - 07/2002
24AdipokinesIBA
01/2022 - 04/2002
23Proteins (Proteins, Gene)FDA Link
01/2022 - 05/2002
17Biomarkers (Surrogate Marker)IBA
05/2022 - 02/2011
16Triglycerides (Triacylglycerol)IBA
09/2022 - 06/2003
16Messenger RNA (mRNA)IBA
02/2014 - 04/2002
13Sitagliptin Phosphate (Januvia)FDA Link
01/2018 - 01/2012
11Hypoglycemic Agents (Hypoglycemics)IBA
06/2022 - 06/2005
11Glucagon (Glukagon)FDA Link
05/2022 - 01/2009
11HDL CholesterolIBA
01/2021 - 11/2005
10Hormones (Hormone)IBA
03/2021 - 10/2002
10HDL LipoproteinsIBA
01/2021 - 02/2007
10CholesterolIBA
01/2021 - 07/2003
9AlbuminsIBA
01/2022 - 09/2007
9Dipeptidyl-Peptidase IV InhibitorsIBA
01/2021 - 01/2013
9LipidsIBA
01/2020 - 02/2011
8Glycated Hemoglobin (Glycosylated Hemoglobin)IBA
09/2022 - 12/2011
8Glucagon-Like Peptide 1 (GLP 1)IBA
04/2022 - 12/2011
8Reactive Oxygen Species (Oxygen Radicals)IBA
04/2022 - 01/2009
8LigandsIBA
01/2022 - 06/2003
8Blood Glucose (Blood Sugar)IBA
01/2020 - 12/2010
8EnzymesIBA
05/2019 - 03/2006
8Pioglitazone (Actos)FDA Link
01/2019 - 06/2005
8Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
08/2017 - 07/2002
7Sodium-Glucose Transporter 2 InhibitorsIBA
04/2022 - 01/2015
7Hemoglobins (Hemoglobin)IBA
04/2022 - 06/2011
7Sucrose (Saccharose)IBA
01/2021 - 01/2003
7LeptinIBA
01/2011 - 05/2002
6Hydrocortisone (Cortisol)FDA LinkGeneric
03/2021 - 01/2013
6alogliptinIBA
01/2021 - 01/2013
6GlucocorticoidsIBA
12/2019 - 03/2012
6CytokinesIBA
01/2019 - 09/2006
5H-cadherin (T-cadherin)IBA
12/2022 - 01/2017
5Sodium-Glucose Transport ProteinsIBA
01/2022 - 01/2015
56- ((4- ethylphenyl)methyl)- 3',4',5',6'- tetrahydro- 6'- (hydroxymethyl)spiro(isobenzofuran- 1(3H),2'- (2H)pyran)- 3',4',5'- triolIBA
01/2022 - 10/2017
5Mineralocorticoid Receptors (Mineralocorticoid Receptor)IBA
12/2021 - 10/2009
5Metformin (Glucophage)FDA LinkGeneric
12/2021 - 01/2012
5glimepiride (Amarel)FDA LinkGeneric
01/2020 - 06/2005
5Indicators and Reagents (Reagents)IBA
12/2018 - 09/2011
5Adrenocorticotropic Hormone (ACTH)FDA Link
11/2016 - 07/2013
5LiraglutideFDA Link
01/2014 - 12/2011
4Uric Acid (Urate)IBA
04/2022 - 07/2012
4ChemokinesIBA
01/2022 - 09/2006
4AldosteroneIBA
12/2021 - 01/2017
4Transcription Factors (Transcription Factor)IBA
12/2021 - 02/2014
4C-PeptideIBA
01/2020 - 08/2017
4Pharmaceutical PreparationsIBA
01/2019 - 11/2003
4Alanine Transaminase (SGPT)IBA
01/2019 - 07/2013
4IncretinsIBA
05/2017 - 03/2010
4Vitamin DFDA LinkGeneric
03/2016 - 12/2012
4AutoantibodiesIBA
06/2015 - 11/2013

Therapy/Procedure

44Therapeutics
06/2022 - 07/2003
27Glycemic Control
06/2022 - 12/2010
5Transplantation
12/2019 - 10/2009